Sidra Rafi

Education

Ph.D. Molecular Medicine from Dr. Panjwani Center for Molecular Medicine and drug Research, University of Karachi.
BS. Medical Technology from Dow University of Health Sciences. Karachi

Working Experience

1. Research Associate at Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), ICCBS, University of Karachi June 2019- March 2020
2. Occupational Trainee: at The University of Sydney, Australia from Sep 2016 to April 2017,
3. Internee in Research & Development Department from Oct – Nov 2015. Herbion Naturals Pvt. Ltd. Karachi, Pakistan
4. Medical lab technologist in Microbiology department from July 2011-Dec 2011. Dow Diagnostic Research and Reference Laboratory (DDRRL)

Dr. Sidra is a recipient of a prestigious scholarship International Research Support Initiative Program by HEC for training in the field of bioinformatics from The University of Sydney, Australia. She has skilfully used his deep understanding of complex biological processes to discover many fascinating molecules with potential therapeutic applications for infectious and metabolic diseases using Bioinformatics approaches. She has worked on multiple projects related to bioinformatics, including database construction, consensus docking approach, subtractive genomic approach, protein-protein interaction, molecular dynamics simulation, mutagenesis, and free energy perturbation methods. She is experienced in analysing and managing massive amounts of data on a supercomputer.

Total Publications: 06

Total Impact Factor: 18.8

Keywords

Computational Biology, Protein-protein interactions, Docking, Bioinformatics, Molecular Medicine

Publication

1. Waraich, R. S., Sohail, F. A., Khan, G., Durr-E-Shahwar, S., Khan, B., Rafi, S., & Nasir, S. (2023). Enhanced Expression of RAGE AXIS Is Associated with Severity of COVID-19 in Patients with Comorbidities. Metabolic Syndrome and Related Disorders.
2. Yousuf, , Rafi, S., Ishrat, U., Shafiga, A., Dashdamirova, G., Leyla, V., & Iqbal, H. (2022). Potential Biological Targets Prediction, ADME Profiling, and Molecular Docking Studies of Novel Steroidal Products from Cunninghamella blakesleana. Medicinal Chemistry, 18(2), 288-305.
3. Zehra, B., Ahmed, A., Khan, A., Shams, A., Uddin, R., Rafi, S., … & Abid Ali, S. (2022). Sesquiterpene from Polygonum barbatum disrupts mitochondrial membrane potential to induce apoptosis and inhibits metastasis by downregulating matrix metalloproteinase and osteopontin in NCI-H460 cells. Naunyn-Schmiedeberg’s Archives of Pharmacology, 395(8), 987-1001.
4. Rafi, Sidra, Sabina Yasmin, and Reaz Uddin. “A Molecular Dynamic Simulation Approach: Development of Dengue Virus Vaccine by Affinity Improvement Techniques.” Journal of Biomolecular Structure and Dynamics (2020): 1-16.
5. Uddin, R., Siraj, B., Rafi, S., Azam, S. S., & Wadood, A. (2020). Structure-based Virtual Screening Approach for the Discovery of Potent Inhibitors of Aminoglycoside 6′-N-Acetyltransferase Type Ib [AAC (6′)-Ib] against K. pneumoniae Infections. Letters in Drug Design & Discovery, 17(8), 1027-1035

Uddin, R., & Rafi, S. (2017). Structural and functional characterization of a unique hypothetical protein (WP_003901628. 1) of Mycobacterium tuberculosis: a computationalapproach. Medicinal Chemistry Research, 26, 1029-1041.