Postdoctoral Fellow, Northwestern University Chicago, USA-2010.
Postdoctoral Fellow, CAS Beijing, China 2013
PhD, University of Tubingen, Germany-2008
MSc. University of Karachi-2000
Professional Membership:
European Association of the Study of Diabetes (EASD)
American Diabetes Association (ADA)
International Diabetes Federation
Experience
Professor, 2019 till present, Sohail University, Karachi
Associate professor; 2018-2019 Jinnah Medical & Dental College, Karachi
Assistant professor; 2008-2017, International Centre for Chemical & Biological Sciences, University of Karachi, Karachi
Secured several national & international research grants.
Conceived and established institutional development projects at universities.
Research Interest
I am deciphering underlying molecular mechanisms of risk factors in etiology & pathophysiology of cancer, metabolic & neurological diseases. My published work explains how advanced glycation end products play role in the development of diabetes, metabolic syndrome & Alzheimer’s diseases? The motivation is to enhance civic knowledge & to shape government policies on preventive interventions that will consequently reduce the burden of aforementioned diseases at national level. Advance cell culture, molecular & cell biology techniques are routinely practiced in our research.
Keywords
Metabolic diseases, signal transduction, inflammation, oxidative stress, advanced glycation end products
Publications
Murtaza M, Khan G, Aftab MF, Afridi SK, Ghaffar S, Ahmed A, Hafizur RM, Waraich RS. Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway. PLoS One. 2017 Jun 9; 12(6):e0178910. doi: 10.1371/journal.pone.0178910. (ISI, IF: 2.766)
Ghaffar S, Afridi SK, Aftab MF, Murtaza M, Hafizur RM, Sara S, Begum S, Waraich RS. Clove and Its Active Compound Attenuate Free Fatty Acid-Mediated Insulin Resistance in Skeletal Muscle Cells and in Mice. J Med Food. 2017 Apr; 20(4):335-344. doi: 10.1089/jmf.2016.3835. Epub 2017 Mar 24. (ISI, IF: 1.954)
Aftab MF, Afridi SK, Mughal UR, Karim A, Haleem DJ, Kabir N, Khan KM, Hafizur RM, Waraich RS. New isatin derivative inhibits neurodegeneration by restoring insulin signaling in brain. J Chem Neuroanat. 2017 Apr;81: 1-9. doi: 10.1016/j.jchemneu.2017.01.001. Epub 2017 Jan 16. (ISI, IF: 2.162)
Ghaffar S, Afridi SK, Aftab MF, Murtaza M, Sayed SA, Begum S, Waraich RS. Attenuation of palmitate induced insulin resistance in muscle cells by harmala, clove and river red gum. Pak J Pharm Sci. 2016 Oct; 29(5 Suppl), 1795-1800 (ISI, IF: 0.804)
Shabbir Khan Afridi, Meha Fatima Aftab, Munazza Murtaza ,Safina Ghaffar ,Aneela Karim , Uzma Rasool Mughal , Khalid Mohammed Khan , Rizwana Sanaullah Waraich A new glycotoxins inhibitor attenuates insulin resistance in liver and fat cells. Biochem Biophys Res Commun. 2016 May 16. [Epub ahead of print]. (ISI, IF: 2.559)
Aftab MF, Afridi SK, Ghaffar S, Murtaza M, Khan M, Karim A, Khan KM, Waraich RS. A bis-Schiff base of isatin improves methylglyoxal mediated insulin resistance in skeletal muscle cells. Arch Pharm Res. 2015 Oct 30. [Epub ahead of print] PMID: 26519157 (ISI, IF: 2.33)
Rizwana S. Waraich and Franck Mauvais-Jarvis* Paracrine and intracrine contributions of androgens and estrogens to adipose tissue biology: physiopathological aspects Horm Mol Biol Clin Invest 2013 (Review)
Nohara K, Waraich RS, Liu S, Ferron M, Waget A, Meyers MS, Karsenty G, Burcelin R, Mauvais-Jarvis F. Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice.Am J Physiol Endocrinol Metab. 2013 Jun 15; 304(12):E1321-30. Doi: 10.1152/ajpendo.00620.2012. Epub 2013 Apr 23. (ISI, IF: 4.018)
Meha Fatima Aftab and Rizwana S. Waraich A review of biochemical markers for early Diagnosis of alzheimer’s disease. American Journal of Neuroscience, 2012, 3 (2), 54-62 (Review)
Nohara K, Zhang Y, Waraich RS, Laque A, Tiano JP, Tong J, Münzberg H, Mauvais-Jarvis F. H Early-life exposure to testosterone programs the hypothalamic melanocortin system. Endocrinology. 2011 Apr; 152(4):1661-9. Epub 2011 Feb 8. (ISI, IF: 3.961)
Waraich RS, Zaidi N, Moeschel K, Beck A, Weigert C, Voelter W, Kalbacher H, Lehmann R.H. Development and precise characterization of phospho-site-specific antibody of Ser (357) of IRS-1: Elimination of cross reactivity with adjacent Ser (358). Biochem Biophys Res Commun. 2008 Aug 24. [Epub ahead of print]PMID: 18725197 [PubMed – as supplied by publisher] (ISI, IF: 2.559)
Waraich RS, Weigert C, Kalbacher H, Hennige AM, Lutz SZ, Häring HU, Schleicher ED, Voelter W, Lehmann R. Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. J Biol Chem. 2008 Apr 25; 283(17):11226-33. Epub 2008 Feb 19. PMID: 18285345 [PubMed – indexed for MEDLINE] (ISI, IF: 4.010)
Noor Fatima1, Areeba Khaleeq2, Shahrukh Momin1, Rizwana S Waraich1, Saima Khaliq2 and Rahman M Hafizur1* Modulation of Pancreatic β-Cells and Antioxidant Status by Cinnamon in Type 2 Diabetic Rats J Cytol Histol 2017 8: 477, Vol 8(4) (X cataegory)
The Possible Potency of Ocimumbasilicum New Constituent on Glucose-Stimulated Insulin Secretion In vitro and β-cell Function In vivoHumaAslam Bhatti1, Kiran Maryam2, Rizwana S. Waraich2, Abdul Hameed2and Rahman M. Hafizur2 Letters in Drug Design & Discovery,Volume 14, 2017, DOI: 2174/1570180814666171113155732 (ISI, IF: 0.924)
Hafizur, R. M., Maryam, K., Hameed, A., Bano, S., Sumbul, S., Sana, A. Waraich, R. S., Faizi, S. (2018). Insulin releasing effect of some pure compounds from Moringa oleifera on mice islets. Medicinal Chemistry Research, 27(5), 1408-1418. (ISI, IF: 607)
Salman, T., Nawaz, S., Waraich, R. S., & Haleem, D. J. (2019). Repeated administration of methylphenidate produces reinforcement and downregulates 5-HT-1A receptor expression in the nucleus accumbens. Life Sciences, 218, 139-146. (ISI, IF: 3.234)
